A Fully-Integrated Analog Front-End for Magnetic-Sensitivity Biosensor

LI Zhong-qiu; CHEN Cheng-ying; HE Ying

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A Fully-Integrated Analog Front-End for Magnetic-Sensitivity Biosensor

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- A Fully-Integrated Analog Front-End for Magnetic-Sensitivity Biosensor
- Vol. 33, Issue 3, Pages: 149-154(2016)
- 作者机构：
  
  1. 空军航空维修技术学院,湖南,长沙,410000
  2. 中国科学院机构微电子研究所,北京,100029
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2016
- 稿件说明：
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李仲秋, 陈铖颖, 贺瑛. 一种全集成磁敏生物传感器模拟前端电路[J]. 微电子学与计算机, 2016, 33(3): 149-154.

LI Zhong-qiu, CHEN Cheng-ying, HE Ying. A Fully-Integrated Analog Front-End for Magnetic-Sensitivity Biosensor[J]. 2016, 33(3): 149-154.
李仲秋, 陈铖颖, 贺瑛. 一种全集成磁敏生物传感器模拟前端电路[J]. 微电子学与计算机, 2016, 33(3): 149-154. DOI：

LI Zhong-qiu, CHEN Cheng-ying, HE Ying. A Fully-Integrated Analog Front-End for Magnetic-Sensitivity Biosensor[J]. 2016, 33(3): 149-154. DOI：

摘要

提出一种全集成磁敏模拟前端电路

包括读出电路和10 bit/1 MHz逐次逼近模数转换器两部分

应用于巨磁阻生物传感器; 读出电路提供300 mV偏置电压加载至巨磁阻生物传感器阵列上

将巨磁阻生物传感器阵列上的等效电阻变化转换为电流变化

跨阻放大器将检测电流转换为电压并进行放大; 逐次逼近模数转换器将检测电压转换为数字码

输出至数字电路进行信息处理

完成检测.模拟前端电路采用SMIC 0.18μm 1P6M CMOS工艺实现

工作电压3.3V.后仿真结果表明

在1 MHz时钟频率下

模拟前端电路的输出信号有效精度达到7.8 bit

达到磁敏生物微弱信号的检测电路系统要求.

Abstract

For Giant Magnetoresistance (GMR) Biosensor application an Analog Front-End (AFE) circuit is presented in this paper

which consists of readout circuitand 10 bit/1 MHz Successive Approximation Analog-to-Digital Converter (SAR ADC). The readout circuit provides 300 mV bias voltage for GMR biosensor array

which transfers the resistor change into current change. Then the current is transferred into voltage and amplified by Trans-Impedance Amplifier (TIA). Finally the digital code is output by SAR ADC and processed by DSP. The AFE is implemented in SMIC 0.18 μm 1P6M CMOS process. The power supply is 3.3 V.The measurement results show that

in 1 MHz clock frequency

the ENOB of circuit is 7.8 bit

meets the requirement for GMR biosensor detection.

关键词

Keywords

references

RAZAVI B. Design of analog CMOS and integrated circuit[M]. McGraw-Hill Company, Inc, 2001: 309-324.

Huang G Y, Liu C C, Lin Y Z, et al, A10-bit 12-MS/s successive approximation ADC with 1.2-pF input capacitance[C]// IEEE Asian Solid-State Circuit Conference. Taipei: IEEE, 2009 : 157-160.

Siamak M, Edward L. A 1-V, 8-Bit successive approximation ADC in standard CMOS process[J]. IEEE Journal of Solid-State Circuits, 2000, 35(4): 642-646. DOI: 642

Gilbert P. 12-bit Low-power fully differential switch capacitor noncalibrating successive approximation ADC with 1MS/s [J]. IEEE Journal of Solid-State Circuit, 2001, 36(7): 1138-1143. DOI: 1138

Rife J C, Miller M M, Sheehen P E, et al. Design and performance of GMR sensors for the detection of magnetic mocrobeads in biosensors[J]. Sensor and Actuators, 2003, 107(3): 209-218. DOI: 209

Miller MM, Sheehen P E, Edelstein R L, et al. A DNA array sensor utilizing magnetic microbeads and magnetoeletronic detection[J]. Journal of Magnetism and Magnetic Materials, 2001, 225(1-2) : 138-144. DOI: 138

Baibich M N, Broto J U, Fert A, et al. Giant magnetoresistance of FeCr magnetic syperlattices[J]. Physical Letters, 1988, 61(21): 2472-2475. DOI: 2472

NaveenV, Anantha C. An ultra low energy 12-bit rate-resolution scalable SAR ADC for wireless sensor nodes[J]. IEEE Journal of Solid-State Circuits, 2007, 42(6) : 1196-1205. DOI: 1196

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