A Charge-balanced Programmable Pulse Generator Circuit for Implantable Cardiac Pacemaker

YAN Chen; ZHANG Rui-zhi; JIAO Zi-hao; XU Jiang-tao; ZHANG Hong

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A Charge-balanced Programmable Pulse Generator Circuit for Implantable Cardiac Pacemaker

更新时间：2026-09-04

- A Charge-balanced Programmable Pulse Generator Circuit for Implantable Cardiac Pacemaker
- Vol. 35, Issue 3, Pages: 58-63(2018)
- 作者机构：
  
  西安交通大学微电子学院,陕西,西安,710049
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2018
- 稿件说明：
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闫琛, 张瑞智, 焦子豪, 许江涛, 张鸿. 用于植入式心脏起搏器可编程电荷平衡脉冲产生电路[J]. 微电子学与计算机, 2018, 35(3): 58-63.

YAN Chen, ZHANG Rui-zhi, JIAO Zi-hao, et al. A Charge-balanced Programmable Pulse Generator Circuit for Implantable Cardiac Pacemaker[J]. 2018, 35(3): 58-63.
闫琛, 张瑞智, 焦子豪, 许江涛, 张鸿. 用于植入式心脏起搏器可编程电荷平衡脉冲产生电路[J]. 微电子学与计算机, 2018, 35(3): 58-63. DOI：

YAN Chen, ZHANG Rui-zhi, JIAO Zi-hao, et al. A Charge-balanced Programmable Pulse Generator Circuit for Implantable Cardiac Pacemaker[J]. 2018, 35(3): 58-63. DOI：

摘要

提出了一种基于电荷泵的植入式心脏起搏器的可编程高压脉冲产生电路

能够保证刺激脉冲对心脏充放电时的电荷平衡

大大降低了起搏器的应用风险.该电路主要包括一个高效率电荷泵、开关电容DAC和基于比较器的脉冲电压检测控制电路

能够精确地调节起搏脉冲的幅值

从而适应不同情况病人的需求.此电路基于HHNEC 0.35 m BCD工艺设计

并用Spectre进行了仿真.

Abstract

A charge-balanced programmable pulse generator is proposed. This circuit has overcome the problem that the amount of charges pass through cardiac unequal between charge and stimulate phase

and deduces the security risk. This circuit mainly includes a high efficiency charge pump circuit

DAC and pulse control circuit based on comparator

and its adjustable character suits for different patients. This circuit is based on HHNEC 0.35 BCD technology and simulated through Spectre.

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references

Ward C, Henderson S, Metcalfe N H. A short history on pacemakers[J]. International Journal of Cardiology, 2013, 169(4): 244-248. DOI: 244

Razavi B. The Strong Arm latch[J]. IEEE Solid-State Circuits Mag., 2015, 7(2): 12-17. DOI: 12

刘华芬, 王晓红, 向晋涛, 等. 与起搏器有关的并发症案例报道10年回顾分析[J]. 中国心脏起搏与心电生理杂志, 2007, 21(4): 370-373. DOI: 370

Starzyk J, Jan Y, Qiu F. A DC-DC charge pump design based on voltagedoublers[J]. IEEE Trans. Circuits Syst. I, 2001, 48(3): 350-359. DOI: 350

张瑞智, 赵阳, 张鸿, 等. 一种应用于心脏起搏器的极性选择电路[D]. 西安: 西安交通大学, 2015.

Powers R A. Batteries for low power electronics[J]. Proceedings of the IEEE, 1995, 83 (4): 687-693. DOI: 687

Zhang J, Zhang H, Xu J, et al. A low energy ASIC for triple-chamber cardiac pacemakers with contact resistance measurement[J]. Microelectronics Journal, 2017, 60: 65-74. DOI: 65

Zhang J, Zhang H, Zhang R, et al. A mixed-signal ASIC for triple-chamber cardiac pacemakers with heart resistance measurement[C]// IEEE Asian Solid-State Circuits Conference. IEEE, 2015: 1-4.

Shuenn-Yuh L, Su Y C, Liang M C, et al. A programmable implantable micro-stimulator SoC with wireless telemetry[C]// Application in closed-loop endocardial stimulation for cardiac pacemaker. IEEE, 2011: 44-45.

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