A Capacitively-Coupled Biomedical Instrumentati on Amplifier with Novel Ripple Reduction Loop

QIN Zheng; DONG Yang-tao; ZHAO Meng-lian; WU Xiao-bo

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A Capacitively-Coupled Biomedical Instrumentati on Amplifier with Novel Ripple Reduction Loop

更新时间：2026-09-04

- A Capacitively-Coupled Biomedical Instrumentati on Amplifier with Novel Ripple Reduction Loop
- Vol. 35, Issue 8, Pages: 31-35(2018)
- 作者机构：
  
  浙江大学超大规模集成电路设计研究所,浙江,杭州,310027
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2018
- 稿件说明：
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秦政, 董阳涛, 赵梦恋, 吴晓波. 一种带有新型纹波抑制环路的电容耦合生物医学仪表放大器[J]. 微电子学与计算机, 2018, 35(8): 31-35.

QIN Zheng, DONG Yang-tao, ZHAO Meng-lian, et al. A Capacitively-Coupled Biomedical Instrumentati on Amplifier with Novel Ripple Reduction Loop[J]. 2018, 35(8): 31-35.
秦政, 董阳涛, 赵梦恋, 吴晓波. 一种带有新型纹波抑制环路的电容耦合生物医学仪表放大器[J]. 微电子学与计算机, 2018, 35(8): 31-35. DOI：

QIN Zheng, DONG Yang-tao, ZHAO Meng-lian, et al. A Capacitively-Coupled Biomedical Instrumentati on Amplifier with Novel Ripple Reduction Loop[J]. 2018, 35(8): 31-35. DOI：

摘要

设计了一种用于扩增生物电信号的低功耗高精度电容耦合斩波仪表放大器.通过斩波来减少失调和1/f噪声

并且利用带有斩波型Ping-Pong结构自调零拓扑的纹波抑制环路来减小由于调制失调电压和1/f噪声而产生的纹波.利用上述结构

斩波纹波在放大器的输出级可衰减约40 dB.采用带有较大时间常数的直流伺服环路可以有效抑制电极失调

同时采用正反馈环路来提高输入阻抗.该仪表放大器采用SMIC 0.18 μm CMOS工艺进行设计.针对EEG或ECG等信号的特点

将放大器-3 dB带宽设置为1 kHz.仿真结果表明

它的等效输入噪声功率谱密度为32 nV/

噪声效率因数为2.1

共模抑制比为105 dB

并且在1 V电压供电下

供电电流达到2.8 μA.

Abstract

This paper describes a low-power precision capacitively-coupled chopper instrumentation amplifier (CCIA) to amplify the bio-potential signals. To reduce the offset and 1/f noise

chopping is employed. And the resulting ripple caused by the up-modulated offset and 1/f noise is suppressed by a proposed ripple reduction loop with chopped Ping-Pong auto-zeroing topology. With the proposed RRL

the chopping ripple at the output stage of the CCIA is attenuated about 40 dB. A DC servo loop (DSL) with a large time constant is employed to suppress electrode offset and a positive feedback loop (PFL) is employed to boost the input impedance. The CCIA is implemented in SMIC 0.18 μm CMOS process. To fit applications like EEG or ECG signals

-3 dB bandwidth is set as 1 kHz. Simulation results show that it achieves an equivalent input noise power spectrum density (PSD) of

a noise efficiency factor (NEF) of 2.1

CMRR of 105 dB and a supply current of 2.8 μA at a 1 V supply voltage.

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references

Fan Q, Sebastiano F, Huijsing J, et al. A 1.8μW 60 nV/rtHz capacitively-coupled chopper instrumentation amplifier in 65 nm CMOS for wireless sensor nodes[J]. IEEE Journal of Solid-State Circuits, 2011, 46(7): 1534-1543. DOI: 1534

Pertijs M, Kindt W. A 140 dB-CMRR current-feedback instrumentation amplifier employing ping-pong auto-zeroing and chopping[J]. IEEE Journal of Solid-State Circuits, 2010, 45(10): 2044-2056. DOI: 2044

Sun P, Zhao M, Wu X, et al. A capacitively-coupled biomedical instrumentation amplifier employing chopping and auto-zeroing[C]//IEEE Biomedical Circuits and Systems Conference. Turin, Italy, 2012: 61-64.

Wu J, Law M K, Mak P I, et al. A 2 μW 45nV/rtHz readout front end with multiple-chopping active-high-pass ripple reduction loop and pseudofeedback DC servo loop[J]. IEEE Transactions on Circuits and Systems-II: Express Briefs, 2016, 63(4): 351-355. DOI: 351

刘召辉.低噪声专用仪表放大器的设计[D].浙江: 浙江大学, 2008.

Wu R, Makinwa K A, Huijsing J H, et al. A chopper current-feedback instrumentation amplifier with a 1 mhz 1/f noise corner and ac-coupled ripple reduction loop[J]. IEEE Journal of Solid-State Circuits, 2011, 44(12): 3232-3243. DOI: 3232

Kusuda Y. Auto correction feedback for ripple suppresion in a chopper amplifier[J]. IEEE Journal of Solid-State Circuits, 2010, 45(8): 573-576. DOI: 573

付蓉.用于脑机接口的脑电信号数据采集系统设计[D].江西: 南昌大学, 2015.

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