Effect of surface grain boundary density on preosteoblast proliferation on titanium

Terry C. Lowe; Rebecca A. Reiss; Patrick E. Illescas; Casey F. Davis; Melanie C. Connick; Johnny A. Sena

doi:10.1080/21663831.2020.1744758

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Effect of surface grain boundary density on preosteoblast proliferation on titanium

Report | 更新时间：2026-08-19

- Effect of surface grain boundary density on preosteoblast proliferation on titanium
- Materials Research Letters Vol. 8, Issue 6, Pages: 239-246(2020)
- 作者机构：
  
  1. S. Ansell Department of Metallurgical and Materials Engineering Colorado School of Mines Golden,George
  2. Biology Department New Mexico Institution of Mining and Technology Socorro
  3. National Center for Genome Resources Santa Fe
- 作者简介：
- 基金信息：
- DOI：10.1080/21663831.2020.1744758
  CLC：
- Online First：07 April 2020，
  
  Published：2020
- 稿件说明：
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Terry C. Lowe, Rebecca A. Reiss, Patrick E. Illescas, et al. Effect of surface grain boundary density on preosteoblast proliferation on titanium[J]. Materials Research Letters, 2020, 8(6): 239-246.
DOI：

Terry C. Lowe, Rebecca A. Reiss, Patrick E. Illescas, et al. Effect of surface grain boundary density on preosteoblast proliferation on titanium[J]. Materials Research Letters, 2020, 8(6): 239-246. DOI： 10.1080/21663831.2020.1744758.

摘要

Abstract

BSTRACTStudies since 2004 have shown that the cytocompatibility of ultrafine grain (UG) commercial purity (CP) titanium exceeds that of coarse grain (CG) CP titanium (Ti) by 30% to 20-fold. To isolate the factors affecting this large reported variability of CP titanium’s cytocompatibility

discs of UG and CG titanium were fabricated with controlled texture and roughness. The discs were seeded with MC3T3-E1 pre-osteoblastic cells and cultured for 72 h. The proliferation of cells on polished UG-Ti exceeded unpolished CG-Ti 3.04-fold. Cell proliferation was found to correlate with a new biophysical parameter

the average grain boundary length per surface-attached cell.

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