The fatigue strength coefficient and fatigue ductility coefficient in total strain life equation for a material can be determined by the monotonic tensile ultimate strength and percentage reduction of area of specimens. A method was investigated to determine the fatigue strength exponent and fatigue ductility exponent in total strain life equation by use of the monotonic tensile elongation and the fatigue test data under two different stress amplitudes. An analysis procedure was developed to determine all the four parameters in the total strain life equation according to a few fatigue test data and the monotonic tensile mechanical performance parameters. This method was verified by use of the fatigue test data of several titanium alloys and nickelbased alloys commonly used in aeroengine. The results indicate that the total strain life equation with its parameters obtained by use of the developed method can make a relatively accurate fatigue life prediction nearly within a scatter band of 3.