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西安交通大学 基础医学院,陕西 西安 710061
Received:12 May 2026,
Online First:13 July 2026,
Published:15 July 2026
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李盈,李凯.细胞外囊泡调控肿瘤机制及诊疗应用进展[J].宁夏大学学报(自然科学版中英文),2026,47(4):356-370.
LI Ying,LI Kai.Progress in Regulation Mechanism of Tumor by Extracellular Vesicles and Its Diagnostic and Therapeutic Applications[J].Journal of Ningxia University (Natural Science Edition in Chinese and English),2026,47(4):356-370.
李盈,李凯.细胞外囊泡调控肿瘤机制及诊疗应用进展[J].宁夏大学学报(自然科学版中英文),2026,47(4):356-370. DOI: 10.20176/j.cnki.nxdz.20260704.
LI Ying,LI Kai.Progress in Regulation Mechanism of Tumor by Extracellular Vesicles and Its Diagnostic and Therapeutic Applications[J].Journal of Ningxia University (Natural Science Edition in Chinese and English),2026,47(4):356-370. DOI: 10.20176/j.cnki.nxdz.20260704.
细胞外囊泡(extracellular vesicles, EVs)是介导细胞间通讯的关键介质,可参与原核生物与高等真核生物的胞间信号传导,调控多种生物学过程。近十年来,EVs在各类疾病、特别是在恶性肿瘤中的病理生理机制得到持续深入解析,相关研究也促进了其在肿瘤诊断与治疗领域的转化探索及临床应用。为此,论文系统综述EVs的生成过程及其在肿瘤发生发展中的调控机制相关研究进展,深入探讨EVs应用于肿瘤临床诊疗的前景与存在的挑战。
Extracellular vesicles (EVs) are key mediators of intercellular communication. They participate in intercellular signaling among prokaryotes and higher eukaryotes and regulate a wide range of biological processes. Over the past decade, the pathophysiological roles of EVs in various diseases, especially malignant tumors, have been extensively investigated. These advances have also promoted the translational development and clinical application of EVs in tumor diagnosis and treatment. This review systematically summarizes recent progress in the biogenesis of EVs and the mechanisms by which they regulate tumor initiation and progression. It further discusses the prospects and current challenges associated with the clinical application of EVs in tumor diagnosis and treatment.
Bray F , Laversanne M , Sung H , et al . Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA , 2024 , 74 ( 3 ): 229 - 263 .
Jain R K . Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers [J]. Journal of Clinical Oncology , 2013 , 31 ( 17 ): 2205 - 2218 .
Cao Lideng , Li Zaiye , Song Jian , et al . Sequential drug release system: Targeting the tumor ECM for enhanced chemotherapy efficacy [J/OL]. Proceedings of the National Academy of Sciences of the United States of America , 2025 , 122 ( 23 ): e2421061122 . https://doi/org/10.1073/pnas.2421061122 https://doi/org/10.1073/pnas.2421061122 .
Cai Yifan , Zhang Zichen , Lu Yi , et al . Liposomal particokinetics and intratumoral microdistribution: A quantitative reassessment of the enhanced permeability and retention effect [J/OL]. Journal of Controlled Release , 2026 , 393 : 114759 . https://doi/org/10.1016/j.jconrel.2026.114759 https://doi/org/10.1016/j.jconrel.2026.114759 .
Cheng Y H , He Chunla , Riviere J E , et al . Meta-analysis of nanoparticle delivery to tumors using a physiologically based pharmacokinetic modeling and simulation approach [J]. ACS Nano , 2020 , 14 ( 3 ): 3075 - 3095 .
Valadi H , Ekström K , Bossios A , et al . Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells [J]. Nature Cell Biology , 2007 , 9 ( 6 ): 654 - 659 .
Raposo G , Nijman H W , Stoorvogel W , et al . B lymphocytes secrete antigen-presenting vesicles [J]. The Journal of Experimental Medicine , 1996 , 183 ( 3 ): 1161 - 1172 .
Laulagnier K , Javalet C , Hemming F J , et al . Amyloid precursor protein products concentrate in a subset of exosomes specifically endocytosed by neurons [J]. Cellular and Molecular Life Sciences , 2018 , 75 ( 4 ): 757 - 773 .
Ngolab J , Trinh I , Rockenstein E , et al . Correction to: Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology [J/OL]. Acta Neuropathologica Communications , 2020 , 8 ( 1 ): 123 . https://doi.org/10.1186/s40478-017-0445-5 https://doi.org/10.1186/s40478-017-0445-5 .
Jansen F , Yang Xiaoyan , Baumann K , et al . Endothelial microparticles reduce ICAM-1 expression in a microRNA-222-dependent mechanism [J]. Journal of Cellular and Molecular Medicine , 2015 , 19 ( 9 ): 2202 - 2214 .
van Balkom B W M , de Jong O G , Smits M , et al . Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells [J]. Blood , 2013 , 121 ( 19 ): 3997 - 4006 .
Zhu Fengming , Chong Lee Shin O L S , Pei Guangchang , et al . Adipose-derived mesenchymal stem cells employed exosomes to attenuate AKI-CKD transition through tubular epithelial cell dependent Sox9 activation [J]. Oncotarget , 2017 , 8 ( 41 ): 70707 - 70726 .
Qin Yunhao , Wang Lian , Gao Zhengliang , et al . Bone marrow stromal/stem cell-derived extracellular vesicles regulate osteoblast activity and differentiation in vitro and promote bone regeneration in vivo [J/OL]. Scientific Reports , 2016 , 6 : 21961 . https://doi.org/10.1038/srep21961 https://doi.org/10.1038/srep21961 .
Wang Baochen , Wang Yong , Yan Zhanfu , et al . Colorectal cancer cell-derived exosomes promote proliferation and decrease apoptosis by activating the ERK pathway [J]. International Journal of Clinical and Experimental Pathology , 2019 , 12 ( 7 ): 2485 - 2495 .
Kapogiannis D , Boxer A , Schwartz J B , et al . Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer’s disease [J]. FASEB Journal , 2015 , 29 ( 2 ): 589 - 596 .
Foers A D , Chatfield S , Dagley L F , et al . Enrichment of extracellular vesicles from human synovial fluid using size exclusion chromatography [J/OL]. Journal of Extracellular Vesicles , 2018 , 7 ( 1 ): 1490145 . https://doi/org/10.1080/20013078.2018. 1490145 https://doi/org/10.1080/20013078.2018.1490145 .
Cheng L , Sun Xin , Scicluna B J , et al . Characterization and deep sequencing analysis of exosomal and non-exosomal miRNA in human urine [J]. Kidney International , 2014 , 86 ( 2 ): 433 - 444 .
Lin Yusheng , Dong Hongmei , Deng Weilun , et al . Evaluation of salivary exosomal chimeric GOLM1 - NAA35 RNA as a potential biomarker in esophageal carcinoma [J]. Clinical Cancer Research , 2019 , 25 ( 10 ): 3035 - 3045 .
Théry C , Witwer K W , Aikawa E , et al . Minimal information for studies of extracellular vesicles 2018 (MISEV 2018 ): A position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines[J/OL]. Journal of Extracellular Vesicles , 2018 , 7 ( 1 ): 1535750 . https://doi/org/10.1080/20013078.2018.1535750 https://doi/org/10.1080/20013078.2018.1535750 .
van Niel G , D’Angelo G , Raposo G . Shedding light on the cell biology of extracellular vesicles [J]. Nature Reviews Molecular Cell Biology , 2018 , 19 ( 4 ): 213 - 228 .
Ma Liang , Li Ying , Peng Junya , et al . Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration [J]. Cell Research , 2015 , 25 ( 1 ): 24 - 38 .
Huang Yuwei , Zucker B , Zhang Shaojin , et al . Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains [J]. Nature Cell Biology , 2019 , 21 ( 8 ): 991 - 1002 .
Yu Jinqiang , Yu Li . A decade of migrasome research: Biogenesis, physiological functions, and disease implications [J]. Cell Research , 2025 , 35 ( 9 ): 629 - 641 .
Jiao Haifeng , Li Xiaopeng , Li Ying , et al . Packaged release and targeted delivery of cytokines by migrasomes in circulation [J/OL]. Cell Discovery , 2024 , 10 : 121 . https://doi/org/10.1038/s41421-024- 00749-x https://doi/org/10.1038/s41421-024-00749-x .
胡海婧 , 刘佳升 , 钟健 , 等 . 迁移体的形成机制、生物学功能与研究展望 [J]. 宁夏大学学报(自然科学版中英文) , 2026 , 47 ( 2 ): 158 - 167 .
Jiang Dong , Jiang Zheng , Lu Di , et al . Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation [J]. Nature Cell Biology , 2019 , 21 ( 8 ): 966 - 977 .
Zhu Mingli , Zou Qin , Huang Rongyao , et al . Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells [J]. Cell Research , 2021 , 31 ( 2 ): 237 - 240 .
Jiao Haifeng , Jiang Dong , Hu Xiaoyu , et al . Mitocytosis, a migrasome-mediated mitochondrial quality-control process [J]. Cell , 2021 , 184 ( 11 ): 2896 - 2910.e13 .
Jiang Dong , Jiao Lin , Li Qing , et al . Neutrophil-derived migrasomes are an essential part of the coagulation system [J]. Nature Cell Biology , 2024 , 26 ( 7 ): 1110 - 1123 .
EL Andaloussi S , Mäger I , Breakefield X O , et al . Extracellular vesicles: Biology and emerging therapeutic opportunities [J]. Nature Reviews Drug Discovery , 2013 , 12 ( 5 ): 347 - 357 .
Chivet M , Hemming F , Pernet-Gallay K , et al . Emerging role of neuronal exosomes in the central nervous system [J/OL]. Frontiers in Physiology , 2012 , 3 : 145 . https://doi/org/10.3389/fphys.2012.00145 https://doi/org/10.3389/fphys.2012.00145 .
Jang Y Y , Collector M I , Baylin S B , et al . Hematopoietic stem cells convert into liver cells within days without fusion [J]. Nature Cell Biology , 2004 , 6 ( 6 ): 532 - 539 .
Taylor J , Azimi I , Monteith G , et al . Ca 2+ mediates extracellular vesicle biogenesis through alternate pathways in malignancy [J/OL]. Journal of Extracellular Vesicles , 2020 , 9 ( 1 ): 1734326 . https://doi/org/10.1080/20013078.2020.1734326 https://doi/org/10.1080/20013078.2020.1734326 .
Yu Xin , Harris S L , Levine A J . The regulation of exosome secretion: A novel function of the p53 protein [J]. Cancer Research , 2006 , 66 ( 9 ): 4795 - 4801 .
Kilinc S , Paisner R , Camarda R , et al . Oncogene-regulated release of extracellular vesicles [J]. Developmental Cell , 2021 , 56 ( 13 ): 1989 - 2006.e6 .
Choi D , Montermini L , Meehan B , et al . Oncogenic RAS drives the CRAF-dependent extracellular vesicle uptake mechanism coupled with metastasis [J/OL]. Journal of Extracellular Vesicles , 2021 , 10 ( 8 ): e12091 . https://doi/org/10.1002/jev2.12091 https://doi/org/10.1002/jev2.12091 .
Nakase I , Kobayashi N B , Takatani-Nakase T , et al . Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes [J/OL]. Scientific Reports , 2015 , 5 : 10300 . https://doi/org/10.1038/srep10300 https://doi/org/10.1038/srep10300 .
Lee T H , Chennakrishnaiah S , Audemard E , et al . Oncogenic ras-driven cancer cell vesiculation leads to emission of double-stranded DNA capable of interacting with target cells [J]. Biochemical and Biophysical Research Communications , 2014 , 451 ( 2 ): 295 - 301 .
McKenzie A J , Hoshino D , Hong N H , et al . KRAS-MEK signaling controls Ago2 sorting into exosomes [J]. Cell Reports , 2016 , 15 ( 5 ): 978 - 987 .
Lin S B , Gregory R I . MicroRNA biogenesis pathways in cancer [J]. Nature Reviews Cancer , 2015 , 15 ( 6 ): 321 - 333 .
Melo S A , Sugimoto H , O’Connell J T , et al . Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis [J]. Cancer Cell , 2014 , 26 ( 5 ): 707 - 721 .
Al-Nedawi K , Meehan B , Micallef J , et al . Intercellular transfer of the oncogenic receptor EGFRvⅢ by microvesicles derived from tumour cells [J]. Nature Cell Biology , 2008 , 10 ( 5 ): 619 - 624 .
Skog J , Würdinger T , van Rijn S , et al . Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers [J]. Nature Cell Biology , 2008 , 10 ( 12 ): 1470 - 1476 .
Sidhu S S , Mengistab A T , Tauscher A N , et al . The microvesicle as a vehicle for EMMPRIN in tumor-stromal interactions [J]. Oncogene , 2004 , 23 ( 4 ): 956 - 963 .
Peinado H , Alečković M , Lavotshkin S , et al . Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET [J]. Nature Medicine , 2012 , 18 ( 6 ): 883 - 891 .
Yang Mei , Chen Jingqi , Su Fang , et al . Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells [J/OL]. Molecular Cancer , 2011 , 10 ( 1 ): 117 . https://doi/org/10.1186/1476-4598-10-117 https://doi/org/10.1186/1476-4598-10-117 .
Cai Zhijian , Yang Fei , Yu Lei , et al . Activated T cell exosomes promote tumor invasion via fas signaling pathway [J]. The Journal of Immunology , 2012 , 188 ( 12 ): 5954 - 5961 .
Ma Shaolin , McGuire M H , Mangala L S , et al . Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype [J/OL]. Cell Reports , 2021 , 34 ( 6 ): 108726 . https://doi/org/ 10.1016/j.celrep.2021.108726 https://doi/org/10.1016/j.celrep.2021.108726 .
吴一鸣 , 赵刚 , 王玉炯 . 细胞外囊泡在细菌和病毒感染中的免疫调控作用 [J]. 宁夏大学学报(自然科学版中英文) , 2025 , 46 ( 1 ): 68 - 77 .
Nabet B Y , Qiu Y , Shabason J E , et al . Exosome RNA unshielding couples stromal activation to pattern recognition receptor signaling in cancer [J]. Cell , 2017 , 170 ( 2 ): 352 - 366.e13 .
Donnarumma E , Fiore D , Nappa M , et al . Cancer-associated fibroblasts release exosomal microRNAs that dictate an aggressive phenotype in breast cancer [J]. Oncotarget , 2017 , 8 ( 12 ): 19592 - 19608 .
Park M , Kim J W , Kim K M , et al . Circulating small extracellular vesicles activate TYRO3 to drive cancer metastasis and chemoresistance [J]. Cancer Research , 2021 , 81 ( 13 ): 3539 - 3553 .
Cornell L , Wander S A , Visal T , et al . microRNA-mediated suppression of the TGF- β pathway confers transmissible and reversible CDK4/6 inhibitor resistance [J]. Cell Reports , 2019 , 26 ( 10 ): 2667 - 2680.e7 .
Kreger B T , Johansen E R , Cerione R A , et al . The enrichment of survivin in exosomes from breast cancer cells treated with paclitaxel promotes cell survival and chemoresistance [J/OL]. Cancers , 2016 , 8 ( 12 ): 111 . https://doi/org/10.3390/cancers8120111 https://doi/org/10.3390/cancers8120111 .
Ma Xin , Chen Zhen , Hua Dong , et al . Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance [J]. Proceedings of the National Academy of Sciences of the United States of America , 2014 , 111 ( 17 ): 6389 - 6394 .
Poggio M , Hu Tianyi , Pai C C , et al . Suppression of exosomal PD-L1 induces systemic anti-tumor immunity and memory [J]. Cell , 2019 , 177 ( 2 ): 414 - 427.e13 .
Ma Shaolin , Mangala L S , Hu Wen , et al . CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance [J/OL]. Cell Reports , 2021 , 36 ( 7 ): 109549 . https://doi/org/10.1016/j.celrep.2021.109549 https://doi/org/10.1016/j.celrep.2021.109549 .
Qu Le , Ding Jin , Chen Cheng , et al . Exosome-transmitted lncARSR promotes sunitinib resistance in renal cancer by acting as a competing endogenous RNA [J]. Cancer Cell , 2016 , 29 ( 5 ): 653 - 668 .
Boelens M C , Wu T J , Nabet B Y , et al . Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways [J]. Cell , 2014 , 159 ( 3 ): 499 - 513 .
Sansone P , Savini C , Kurelac I , et al . Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer [J]. Proceedings of the National Academy of Sciences of the United States of America , 2017 , 114 ( 43 ): E9066 - E9075 .
Ignatiadis M , Sledge G W , Jeffrey S S . Liquid biopsy enters the clinic: implementation issues and future challenges [J]. Nature Reviews Clinical Oncology , 2021 , 18 ( 5 ): 297 - 312 .
Yu W , Hurley J , Roberts D , et al . Exosome-based liquid biopsies in cancer: Opportunities and challenges [J]. Annals of Oncology , 2021 , 32 ( 4 ): 466 - 477 .
McKiernan J , Donovan M J , Margolis E , et al . A prospective adaptive utility trial to validate performance of a novel urine exosome gene expression assay to predict high-grade prostate cancer in patients with prostate-specific antigen 2-10 ng/mL at initial biopsy [J]. European Urology , 2018 , 74 ( 6 ): 731 - 738 .
Ji Jin , Chen Rui , Zhao Lin , et al . Circulating exosomal mRNA profiling identifies novel signatures for the detection of prostate cancer [J/OL]. Molecular Cancer , 2021 , 20 ( 1 ): 58 . https://doi/org/10. 1186/s12943-021-01349-z https://doi/org/10.1186/s12943-021-01349-z .
Min Li , Zhu Shengtao , Chen Lei , et al . Evaluation of circulating small extracellular vesicles derived miRNAs as biomarkers of early colon cancer: A comparison with plasma total miRNAs [J/OL]. Journal of Extracellular Vesicles , 2019 , 8 ( 1 ): 1643670 . https://doi/org/10.1080/20013078.2019.1643670 https://doi/org/10.1080/20013078.2019.1643670 .
Guo Xin , Lü Xiaohui , Ru Yi , et al . Circulating exosomal gastric cancer-associated long noncoding RNA1 as a biomarker for early detection and monitoring progression of gastric cancer: A multiphase study [J/OL]. JAMA Surgery , 2020 , 155 ( 7 ): 572 . https://doi/org/10.1001/jamasurg.2020.1133 https://doi/org/10.1001/jamasurg.2020.1133 .
Yang Sujuan , Che S P Y , Kurywchak P , et al . Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer [J]. Cancer Biology & Therapy , 2017 , 18 ( 3 ): 158 - 165 .
Lázaro-Ibáñez E , Lässer C , Shelke G V , et al . DNA analysis of low- and high-density fractions defines heterogeneous subpopulations of small extracellular vesicles based on their DNA cargo and topology [J/OL]. Journal of Extracellular Vesicles , 2019 , 8 ( 1 ): 1656993 . https://doi/org/10.1080/20013078.2019. 1656993 https://doi/org/10.1080/20013078.2019.1656993 .
Hoshino A , Kim H S , Bojmar L , et al . Extracellular vesicle and particle biomarkers define multiple human cancers [J]. Cell , 2020 , 182 ( 4 ): 1044 - 1061.e18 .
Zhang Peng , Wu Xiaoqing , Gardashova G , et al . Molecular and functional extracellular vesicle analysis using nanopatterned microchips monitors tumor progression and metastasis [J/OL]. Science Translational Medicine , 2020 , 12 ( 547 ): eaaz2878 . https://doi/org/10.1126/scitranslmed.aaz2878 https://doi/org/10.1126/scitranslmed.aaz2878 .
Pan Hongchao , Gray R , Braybrooke J , et al . 20-year risks of breast-cancer recurrence after stopping endocrine therapy at 5 years [J]. New England Journal of Medicine , 2017 , 377 ( 19 ): 1836 - 1846 .
Sparano J , O’Neill A , Alpaugh K , et al . Association of circulating tumor cells with late recurrence of estrogen receptor-positive breast cancer: A secondary analysis of a randomized clinical trial [J]. JAMA Oncology , 2018 , 4 ( 12 ): 1700 - 1706 .
Chaudhuri A A , Chabon J J , Lovejoy A F , et al . Early detection of molecular residual disease in localized lung cancer by circulating tumor DNA profiling [J]. Cancer Discovery , 2017 , 7 ( 12 ): 1394 - 1403 .
Tie J , Wang Yuxuan , Tomasetti C , et al . Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage Ⅱ colon cancer [J/OL]. Science Translation Medicine , 2016 , 8 ( 346 ): 346ra92 . https://doi.org/10.1007/s11725-017-0702-6 https://doi.org/10.1007/s11725-017-0702-6 .
Castellanos-Rizaldos E , Grimm D G , Tadigotla V , et al . Exosome-based detection of EGFR T790M in plasma from non-small cell lung cancer patients [J]. Clinical Cancer Research , 2018 , 24 ( 12 ): 2944 - 2950 .
Takahasi K , Iinuma H , Wada K , et al . Usefulness of exosome-encapsulated microRNA-451a as a minimally invasive biomarker for prediction of recurrence and prognosis in pancreatic ductal adenocarcinoma [J]. Journal of Hepato-Biliary-Pancreatic Sciences , 2018 , 25 ( 2 ): 155 - 161 .
Kumata Y , Iinuma H , Suzuki Y , et al . Exosome-encapsulated microRNA-23b as a minimally invasive liquid biomarker for the prediction of recurrence and prognosis of gastric cancer patients in each tumor stage [J]. Oncology Reports , 2018 , 40 ( 1 ): 319 - 330 .
Casadei L , Calore F , Creighton C J , et al . Exosome-derived miR-25-3p and miR-92a-3p stimulate liposarcoma progression [J]. Cancer Research , 2017 , 77 ( 14 ): 3846 - 3856 .
Lim J , Kang B , Son H Y , et al . Microfluidic device for one-step detection of breast cancer-derived exosomal mRNA in blood using signal-amplifiable 3D nanostructure [J/OL]. Biosensors and Bioelectronics , 2022 , 197 : 113753 . https://doi/org/10.1016/j.bios. 2021.113753 https://doi/org/10.1016/j.bios.2021.113753 .
Zhan Yao , Du Lutao , Wang Lishui , et al . Expression signatures of exosomal long non-coding RNAs in urine serve as novel non-invasive biomarkers for diagnosis and recurrence prediction of bladder cancer [J/OL]. Molecular Cancer , 2018 , 17 ( 1 ): 142 . https://doi/org/10.1186/s12943-018-0893-y https://doi/org/10.1186/s12943-018-0893-y .
Shao Huilin , Chung J , Lee K , et al . Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma [J/OL]. Nature Communications , 2015 , 6 : 6999 . https://doi/org/10.1038/ncomms7999 https://doi/org/10.1038/ncomms7999 .
Del Re M , Biasco E , Crucitta S , et al . The detection of androgen receptor splice variant 7 in plasma-derived exosomal RNA strongly predicts resistance to hormonal therapy in metastatic prostate cancer patients [J]. European Urology , 2017 , 71 ( 4 ): 680 - 687 .
Margolis L , Sadovsky Y . The biology of extracellular vesicles: The known unknowns [J/OL]. PLoS Biology , 2019 , 17 ( 7 ): e3000363 . https://doi/org/10.1371/journal.pbio.3000363 https://doi/org/10.1371/journal.pbio.3000363 .
Abramowicz A , Łabaj W , Mika J , et al . MicroRNA profile of exosomes and parental cells is differently affected by ionizing radiation [J]. Radiation Research , 2020 , 194 ( 2 ): 133 - 142 .
Du Yu , Tang Haiyang , Gu Xia , et al . Radiation can regulate the expression of miRNAs associated with osteogenesis and oxidation in exosomes from peripheral blood plasma [J/OL]. Oxidative Medicine and Cellular Longevity , 2021 , 2021 : 6646323 . https://doi/org/10.1155/2021/6646323 https://doi/org/10.1155/2021/6646323 .
Okoye I S , Coomes S M , Pelly V S , et al . microRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells [J]. Immunity , 2014 , 41 ( 1 ): 89 - 103 .
Yang Yang , Sun Mayu , Yao Wenbo , et al . Compound Kushen injection relieves tumor-associated macrophage-mediated immunosuppression through TNFR1 and sensitizes hepatocellular carcinoma to sorafenib [J/OL]. Journal for Immunotherapy of Cancer , 2020 , 8 ( 1 ): e000317 . https://doi/org/ 10.1136/jitc-2019-000317 https://doi/org/10.1136/jitc-2019-000317 .
Cheng L , Hill A F . Therapeutically harnessing extracellular vesicles [J]. Nature Reviews Drug Discovery , 2022 , 21 ( 5 ): 379 - 399 .
Kosgodage U S , Mould R , Henley A B , et al . Cannabidiol (CBD) is a novel inhibitor for exosome and microvesicle (EMV) release in cancer [J/OL]. Frontiers in Pharmacology , 2018 , 9 : 889 . https://doi/org/10.3389/fphar.2018.00889 https://doi/org/10.3389/fphar.2018.00889 .
Kosgodage U S , Trindade R P , Thompson P R , et al . Chloramidine/bisindolylmaleimide-I-mediated inhibition of exosome and microvesicle release and enhanced efficacy of cancer chemotherapy [J/OL]. International Journal of Molecular Sciences , 2017 , 18 ( 5 ): 1007 . https://doi/org/10.3390/ ijms18051007 https://doi/org/10.3390/ijms18051007 .
Kawamoto T , Ohga N , Akiyama K , et al . Tumor-derived microvesicles induce proangiogenic phenotype in endothelial cells via endocytosis [J/OL]. PLoS One , 2012 , 7 ( 3 ): e34045 . https://doi/org/10.1371/ journal.pone.0034045 https://doi/org/10.1371/journal.pone.0034045 .
Mendt M , Kamerkar S , Sugimoto H , et al . Generation and testing of clinical-grade exosomes for pancreatic cancer [J/OL]. JCI Insight , 2018 , 3 ( 8 ): e99263 . https://doi/org/10.1172/jci.insight.99263 https://doi/org/10.1172/jci.insight.99263 .
Kamerkar S , LeBleu V S , Sugimoto H , et al . Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer [J]. Nature , 2017 , 546 ( 7659 ): 498 - 503 .
Yong Tuying , Zhang Xiaoqiong , Bie N N , et al . Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy [J/OL]. Nature Communications , 2019 , 10 : 3838 . https://doi/org/10.1038/s41467-019-11718-4 https://doi/org/10.1038/s41467-019-11718-4 .
Kim M S , Haney M J , Zhao Yuling , et al . Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells [J]. Nanomedicine: Nanotechnology, Biology and Medicine , 2016 , 12 ( 3 ): 655 - 664 .
Saari H , Lázaro-Ibáñez E , Viitala T , et al . Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells [J]. Journal of Controlled Release , 2015 , 220 : 727 - 737 .
Kamerkar S , Leng C R , Burenkova O , et al . Exosome-mediated genetic reprogramming of tumor-associated macrophages by exoASO-STAT6 leads to potent monotherapy antitumor activity [J/OL]. Science Advances , 2022 , 8 ( 7 ): eabj7002 . https://doi/org/10.1126/sciadv.abj7002 https://doi/org/10.1126/sciadv.abj7002 .
McAndrews K M , Xiao Fei , Chronopoulos A , et al . Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic Kras G12D in pancreatic cancer [J/OL]. Life Science Alliance , 2021 , 4 ( 9 ): e202000875 . https://doi/org/10.26508/lsa.202000875 https://doi/org/10.26508/lsa.202000875 .
Usman W M , Pham T C , Kwok Y Y , et al . Efficient RNA drug delivery using red blood cell extracellular vesicles [J/OL]. Nature Communications , 2018 , 9 : 2359 . https://doi/org/10.1038/s41467-018- 04791-8 https://doi/org/10.1038/s41467-018-04791-8 .
Pomatto M A C , Bussolati B , D’Antico S , et al . Improved loading of plasma-derived extracellular vesicles to encapsulate antitumor miRNAs [J]. Molecular Therapy-Methods & Clinical Development , 2019 , 13 : 133 - 144 .
Ohno S I , Takanashi M , Sudo K , et al . Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells [J]. Molecular Therapy , 2013 , 21 ( 1 ): 185 - 191 .
Liu Jia , Ye Zhilan , Xiang Mengxi , et al . Functional extracellular vesicles engineered with lipid-grafted hyaluronic acid effectively reverse cancer drug resistance [J/OL]. Biomaterials , 2019 , 223 : 119475 . https://doi/org/10.1016/j.biomaterials.2019.119475 https://doi/org/10.1016/j.biomaterials.2019.119475 .
Shi Kai , Fang Yan , Gao Shan , et al . Inorganic kernel-supported asymmetric hybrid vesicles for targeting delivery of STAT 3 -decoy oligonucleotides to overcome anti-HER2 therapeutic resistance of BT 474 R [J]. Journal of Controlled Release , 2018 , 279 : 53 - 68 .
Peng Boya , Nguyen T M , Jayasinghe M K , et al . Robust delivery of RIG-I agonists using extracellular vesicles for anti-cancer immunotherapy [J/OL]. Journal of Extracellular Vesicles , 2022 , 11 ( 4 ): e12187 . https://doi/org/10.1002/jev2.12187 https://doi/org/10.1002/jev2.12187 .
André F , Chaput N , Schartz N E , et al . Exosomes as potent cell-free peptide-based vaccine. I. Dendritic cell-derived exosomes transfer functional MHC class I/peptide complexes to dendritic cells [J]. Journal of Immunology (Baltimore , Md, 2004 , 172 ( 4 ): 2126 - 2136 .
Wahlund C J E , Güclüler G , Hiltbrunner S , et al . Exosomes from antigen-pulsed dendritic cells induce stronger antigen-specific immune responses than microvesicles in vivo [J/OL]. Scientific Reports , 2017 , 7 : 17095 . https://doi/org/10.1038/s41598-017-16609-6 https://doi/org/10.1038/s41598-017-16609-6 .
Xiong Xiao , Ke Xiurong , Wang Lu , et al . Neoantigen-based cancer vaccination using chimeric RNA-loaded dendritic cell-derived extracellular vesicles [J/OL]. Journal of Extracellular Vesicles , 2022 , 11 ( 8 ): e12243 . https://doi/org/10.1002/jev2.12243 https://doi/org/10.1002/jev2.12243 .
Fu Wenyan , Lei Changhai , Liu Shuowu , et al . CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity [J/OL]. Nature Communications , 2019 , 10 : 4355 . https://doi/org/10.1038/s41467-019-12321-3 https://doi/org/10.1038/s41467-019-12321-3 .
Dooley K , McConnell R E , Xu Ke , et al . A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties [J]. Molecular Therapy , 2021 , 29 ( 5 ): 1729 - 1743 .
Watson D C , Yung B C , Bergamaschi C , et al . Scalable, cGMP-compatible purification of extracellular vesicles carrying bioactive human heterodimeric IL-15/lactadherin complexes [J/OL]. Journal of Extracellular Vesicles , 2018 , 7 ( 1 ): 1442088 . https://doi/org/10.1080/20013078.2018.1442088 https://doi/org/10.1080/20013078.2018.1442088 .
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