Two-dimensional (2D) heterostructures have recently attracted interest as candidate materials for classical optoelectronics and in quantum information technology. Despite significant research

realizing deterministic

in-plane quantum confinement in synthetic 2D heterostructures at the nanoscale remains challenging. In this brief overview

we summarize recent advances in approaches for the growth of spatially controllable 2D quantum heterostructures. These growth methods enable the achievement of various 2D lateral/vertical heterostructures with controlled positions and dimensions while minimizing defects across the heterointerfaces. In addition

we provide an outlook on the future direction of developments and applications of 2D quantum-confined heterostructures.